Felipe Fregni, MD, PhD, MPH

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Assistant Professor 
ffregni@partners.org  (617) 952-5322

Director of the Labortory of Neuromodulation 

Education:
1999 M.D., University of Sao Paulo  2004 PH.D.,
University of Sao Paulo  2006 M.M.SC.
Scholars in Clinical Science Program, Harvard Medical School  2007 M.P.H. Clinical Effectiveness, Harvard School Of Public Health 
01/01-12/03 Neurology Resident, University of Sao Paulo (Clinics Hospital) 
01/03-12/05 Post Doctoral Fellow, Neuroscience, Beth Israel Deaconess Medical Center (East)  01/04-12/04 Visiting Fellow, Neurophysiology, Federal University of Pernambuco 
01/04-12/04 Visiting Fellow Clinical Neurophysiology, University of Goettingen 

Research investigations 
1. Fregni F, Santos CM, Myczkowski ML, Rigolino R, Gallucci-Neto J, Barbosa ER, Valente KD, Pascual-Leone A, Marcolin MA. Repetitive transcranial magnetic stimulation is as effective as fluoxetine in the treatment of depression in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 2004;75(8):1171-4. 
2. Bermpohl F, Fregni F, Boggio PS, Thut G, Northoff G, Otachi PT, Rigonatti SP, Marcolin MA, Pascual-Leone A. Left prefrontal repetitive transcranial magnetic stimulation impairs performance in affective go/no-go task. Neuroreport 2005;16(6):615-9. 
3. Boggio PS, Fregni F, Bermpohl F, Mansur CG, Rosa M, Rumi DO, Barbosa ER, Odebrecht Rosa M, Pascual-Leone A, Rigonatti SP, Marcolin MA, Araujo Silva MT. Effect of repetitive TMS and fluoxetine on cognitive function in patients with Parkinson's disease and concurrent depression. Mov Disord 2005;20(9):1178-84. 
4. Fregni F, Boggio PS, Mansur CG, Wagner T, Ferreira MJ, Lima MC, Rigonatti SP, Marcolin MA, Freedman SD, Nitsche MA, Pascual-Leone A. Transcranial direct current stimulation of the unaffected hemisphere in stroke patients. Neuroreport 2005;16(14):1551-5. 
5. Fregni F, Boggio PS, Nitsche M, Bermpohl F, Antal A, Feredoes E, Marcolin MA, Rigonatti SP, Silva MT, Paulus W, Pascual-Leone A. Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Exp Brain Res 2005;166(1):23-30. 
6. Fregni F, Monte-Silva KK, Oliveira MB, Freedman SD, Pascual-Leone A, Guedes RC. Lasting accelerative effects of 1 Hz and 20 Hz electrical stimulation on cortical spreading depression: relevance for clinical applications of brain stimulation. Eur J Neurosci 2005;21(8):2278-84. 
7. Kahn I, Pascual-Leone A, Theoret H, Fregni F, Clark D, Wagner AD. Transient disruption of ventrolateral prefrontal cortex during verbal encoding affects subsequent memory performance. J Neurophysiol 2005;94(1):688-98.
 8. Mansur CG, Fregni F, Boggio PS, Riberto M, Gallucci-Neto J, Santos CM, Wagner T, Rigonatti SP, Marcolin MA, Pascual-Leone A. A sham stimulation-controlled trial of rTMS of the unaffected hemisphere in stroke patients. Neurology 2005;64(10):1802-4. 
9. Rumi DO, Gattaz WF, Rigonatti SP, Rosa MA, Fregni F, Rosa MO, Mansur C, Myczkowski ML, Moreno RA, Marcolin MA. Transcranial magnetic stimulation accelerates the antidepressant effect of amitriptyline in severe depression: a double-blind placebo-controlled study. Biol Psychiatry 2005;57(2):162-6. 
10. Theoret H, Halligan E, Kobayashi M, Fregni F, Tager-Flusberg H, Pascual-Leone A. Impaired motor facilitation during action observation in individuals with autism spectrum disorder. Curr Biol 2005;15(3):R84-5. 
11. Bermpohl F, Fregni F, Boggio PS, Thut G, Northoff G, Otachi PT, Rigonatti SP, Marcolin MA, Pascual-Leone A. Effect of low-frequency transcranial magnetic stimulation on an affective go/no-go task in patients with major depression: role of stimulation site and depression severity. Psychiatry Res 2006;141(1):1-13. 
12. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy. Hum Brain Mapp 2006;27(8):662-77. 
13. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Dissociable networks for the expectancy and perception of emotional stimuli in the human brain. Neuroimage 2006;30(2):588-600. 
14. Boggio PS, Alonso-Alonso M, Mansur CG, Rigonatti SP, Schlaug G, Pascual-Leone A, Fregni F. Hand function improvement with low-frequency repetitive transcranial magnetic stimulation of the unaffected hemisphere in a severe case of stroke. Am J Phys Med Rehabil 2006;85(11):927-30. 
15. Boggio PS, Castro LO, Savagim EA, Braite R, Cruz VC, Rocha RR, Rigonatti SP, Silva MT, Fregni F. Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation. Neurosci Lett 2006;404(1-2):232-6. 
16. Boggio PS, Ferrucci R, Rigonatti SP, Covre P, Nitsche M, Pascual-Leone A, Fregni F. Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease. J Neurol Sci 2006;249(1):31-8. 
17. Carey JR, Fregni F, Pascual-Leone A. rTMS combined with motor learning training in healthy subjects. Restor Neurol Neurosci 2006;24(3):191-9. 
18. Conforto AB, Fregni F, Puglia P, Jr., Leite Cda C, Yamamoto FI, Coracini KF, Scaff M. Comparison between digital subtraction angiography and magnetic resonance angiography in investigation of nonlacunar ischemic stroke in young patients: preliminary results. Arq Neuropsiquiatr 2006;64(2B):353-8. 
19. Dias AE, Barbosa ER, Coracini K, Maia F, Marcolin MA, Fregni F. Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease. Acta Neurol Scand 2006;113(2):92-9. 
20. Fregni F, Boggio PS, Bermpohl F, Maia F, Rigonatti SP, Barbosa ER, Pascual-Leone A. Immediate placebo effect in Parkinson's disease--is the subjective relief accompanied by objective improvement? Eur Neurol 2006;56(4):222-9. 
21. Fregni F, Boggio PS, Lima MC, Ferreira MJ, Wagner T, Rigonatti SP, Castro AW, Souza DR, Riberto M, Freedman SD, Nitsche MA, Pascual-Leone A. A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain 2006;122(1-2):197-209. 
22. Fregni F, Boggio PS, Nitsche MA, Marcolin MA, Rigonatti SP, Pascual-Leone A. Treatment of major depression with transcranial direct current stimulation. Bipolar Disord 2006;8(2):203-4. 
23. Fregni F, Boggio PS, Nitsche MA, Rigonatti SP, Pascual-Leone A. Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression. Depress Anxiety 2006;23(8):482-4. 
24. Fregni F, Boggio PS, Santos MC, Lima M, Vieira AL, Rigonatti SP, Silva MT, Barbosa ER, Nitsche MA, Pascual-Leone A. Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease. Mov Disord 2006;21(10):1693-702. 
25. Fregni F, Boggio PS, Valle AC, Otachi P, Thut G, Rigonatti SP, Marcolin MA, Fecteau S, Pascual-Leone A, Fiore L, Valente K. Homeostatic effects of plasma valproate levels on corticospinal excitability changes induced by 1Hz rTMS in patients with juvenile myoclonic epilepsy. Clin Neurophysiol 2006;117(6):1217-27. 
26. Fregni F, Boggio PS, Valle AC, Rocha RR, Duarte J, Ferreira MJ, Wagner T, Fecteau S, Rigonatti SP, Riberto M, Freedman SD, Pascual-Leone A. A sham-controlled trial of a 5-day course of repetitive transcranial magnetic stimulation of the unaffected hemisphere in stroke patients. Stroke 2006;37(8):2115-22. 
27. Fregni F, Gimenes R, Valle AC, Ferreira MJ, Rocha RR, Natalle L, Bravo R, Rigonatti SP, Freedman SD, Nitsche MA, Pascual-Leone A, Boggio PS. A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia. Arthritis Rheum 2006;54(12):3988-98. 
28. Fregni F, Marcolin MA, Myczkowski M, Amiaz R, Hasey G, Rumi DO, Rosa M, Rigonatti SP, Camprodon J, Walpoth M, Heaslip J, Grunhaus L, Hausmann A, Pascual-Leone A. Predictors of antidepressant response in clinical trials of transcranial magnetic stimulation. Int J Neuropsychopharmacol 2006;9(6):641-54. 
29. Fregni F, Ono CR, Santos CM, Bermpohl F, Buchpiguel C, Barbosa ER, Marcolin MA, Pascual-Leone A, Valente KD. Effects of antidepressant treatment with rTMS and fluoxetine on brain perfusion in PD. Neurology 2006;66(11):1629-37. 
30. Fregni F, Otachi PT, Do Valle A, Boggio PS, Thut G, Rigonatti SP, Pascual-Leone A, Valente KD. A randomized clinical trial of repetitive transcranial magnetic stimulation in patients with refractory epilepsy. Ann Neurol 2006;60(4):447-55. 
31. Fregni F, Thome-Souza S, Nitsche MA, Freedman SD, Valente KD, Pascual-Leone A. A controlled clinical trial of cathodal DC polarization in patients with refractory epilepsy. Epilepsia 2006;47(2):335-42. 
32. Liebetanz D, Fregni F, Monte-Silva KK, Oliveira MB, Amancio-dos-Santos A, Nitsche MA, Guedes RC. After-effects of transcranial direct current stimulation (tDCS) on cortical spreading depression. Neurosci Lett 2006;398(1-2):85-90. 
33. Patrizi F, Freedman SD, Pascual-Leone A, Fregni F. Novel therapeutic approaches to the treatment of chronic abdominal visceral pain. ScientificWorldJournal 2006;6:472-90.  34. Rosa MA, Gattaz WF, Pascual-Leone A, Fregni F, Rosa MO, Rumi DO, Myczkowski M, Silva MF, Mansur C, Rigonatti SP, Jacobsen Teixeira M, Marcolin MA. Comparison of repetitive transcranial magnetic stimulation and electroconvulsive therapy in unipolar non-psychotic refractory depression: a randomized, single-blind study. Int J Neuropsychopharmacol 2006;9(6):667-76. 
35. Wagner T, Fregni F, Eden U, Ramos-Estebanez C, Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial magnetic stimulation and stroke: a computer-based human model study. Neuroimage 2006;30(3):857-70. 
36. Boggio PS, Bermpohl F, Vergara AO, Muniz AL, Nahas FH, Leme PB, Rigonatti SP, Fregni F. Go-no-go task performance improvement after anodal transcranial DC stimulation of the left dorsolateral prefrontal cortex in major depression. J Affect Disord 2007;101(1-3):91-8. 
37. Boggio PS, Nunes A, Rigonatti SP, Nitsche MA, Pascual-Leone A, Fregni F. Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients. Restor Neurol Neurosci 2007;25(2):123-9. 
38. Cappelletti M, Barth H, Fregni F, Spelke ES, Pascual-Leone A. rTMS over the intraparietal sulcus disrupts numerosity processing. Exp Brain Res 2007;179(4):631-42.  39. Cohen R, Boggio P, Fregni F. An evaluation of factors affecting duration of treatment with repetitive transcranial magnetic stimulation for depression. Einstein 2007 2007;5(4):368-71. 
40. Fecteau S, Knoch D, Fregni F, Sultani N, Boggio P, Pascual-Leone A. Diminishing risk-taking behavior by modulating activity in the prefrontal cortex: a direct current stimulation study. J Neurosci 2007;27(46):12500-5. 
41. Fecteau S, Pascual-Leone A, Zald DH, Liguori P, Theoret H, Boggio PS, Fregni F. Activation of prefrontal cortex by transcranial direct current stimulation reduces appetite for risk during ambiguous decision making. J Neurosci 2007;27(23):6212-8. 
42. Fregni F, Liebetanz D, Monte-Silva KK, Oliveira MB, Santos AA, Nitsche MA, Pascual-Leone A, Guedes RC. Effects of transcranial direct current stimulation coupled with repetitive electrical stimulation on cortical spreading depression. Exp Neurol 2007;204(1):462-6. 
43. Kuo MF, Grosch J, Fregni F, Paulus W, Nitsche MA. Focusing effect of acetylcholine on neuroplasticity in the human motor cortex. J Neurosci 2007;27(52):14442-7.  44. Nair DG, Hutchinson S, Fregni F, Alexander M, Pascual-Leone A, Schlaug G. Imaging correlates of motor recovery from cerebral infarction and their physiological significance in well-recovered patients. Neuroimage 2007;34(1):253-63. 
45. Ramos-Estebanez C, Merabet LB, Machii K, Fregni F, Thut G, Wagner TA, Romei V, Amedi A, Pascual-Leone A. Visual phosphene perception modulated by subthreshold crossmodal sensory stimulation. J Neurosci 2007;27(15):4178-81. 
46. Roizenblatt S, Fregni F, Gimenez R, Wetzel T, Rigonatti SP, Tufik S, Boggio PS, Valle AC. Site-specific effects of transcranial direct current stimulation on sleep and pain in fibromyalgia: a randomized, sham-controlled study. Pain Pract 2007;7(4):297-306. 
47. Rosa MA, Rosa MO, Marcolin MA, Fregni F. Cardiovascular effects of anesthesia in ECT: a randomized, double-blind comparison of etomidate, propofol, and thiopental. J ECT 2007;23(1):6-8. 
48. Valle AC, Dionisio K, Pitskel NB, Pascual-Leone A, Orsati F, Ferreira MJ, Boggio PS, Lima MC, Rigonatti SP, Fregni F. Low and high frequency repetitive transcranial magnetic stimulation for the treatment of spasticity. Dev Med Child Neurol 2007;49(7):534-8. 
49. Wagner T, Fregni F, Fecteau S, Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial direct current stimulation: a computer-based human model study. Neuroimage 2007;35(3):1113-24. 
50. Bajwa S, Bermpohl F, Rigonatti SP, Pascual-Leone A, Boggio PS, Fregni F. Impaired interhemispheric interactions in patients with major depression. J Nerv Ment Dis 2008;196(9):671-7. 
51. Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Wrase J, Schlagenhauf F, Bauer M, Heinz A, Schlaug G, Northoff G. Novelty seeking modulates medial prefrontal activity during the anticipation of emotional stimuli. Psychiatry Res 2008;164(1):81-5. 
52. Boggio PS, Rigonatti SP, Ribeiro RB, Myczkowski ML, Nitsche MA, Pascual-Leone A, Fregni F. A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression. Int J Neuropsychopharmacol 2008;11(2):249-54. 
53. Boggio PS, Rocha RR, da Silva MT, Fregni F. Differential modulatory effects of transcranial direct current stimulation on a facial expression go-no-go task in males and females. Neurosci Lett 2008;447(2-3):101-5. 
54. Boggio PS, Sultani N, Fecteau S, Merabet L, Mecca T, Pascual-Leone A, Basaglia A, Fregni F. Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: a double-blind, sham-controlled study. Drug Alcohol Depend 2008;92(1-3):55-60. 
55. Boggio PS, Zaghi S, Lopes M, Fregni F. Modulatory effects of anodal transcranial direct current stimulation on perception and pain thresholds in healthy volunteers. Eur J Neurol 2008;15(10):1124-30. 
56. Cappelletti M, Fregni F, Shapiro K, Pascual-Leone A, Caramazza A. Processing nouns and verbs in the left frontal cortex: a transcranial magnetic stimulation study. J Cogn Neurosci 2008;20(4):707-20. 
57. Cardoso EF, Fregni F, Martins Maia F, Boggio PS, Luis Myczkowski M, Coracini K, Lopes Vieira A, Melo LM, Sato JR, Antonio Marcolin M, Rigonatti SP, Cruz AC, Jr., Reis Barbosa E, Amaro E, Jr. rTMS treatment for depression in Parkinson's disease increases BOLD responses in the left prefrontal cortex. Int J Neuropsychopharmacol 2008;11(2):173-83. 
58. Fregni F, Liguori P, Fecteau S, Nitsche MA, Pascual-Leone A, Boggio PS. Cortical stimulation of the prefrontal cortex with transcranial direct current stimulation reduces cue-provoked smoking craving: a randomized, sham-controlled study. J Clin Psychiatry 2008;69(1):32-40. 
59. Fregni F, Orsati F, Pedrosa W, Fecteau S, Tome FA, Nitsche MA, Mecca T, Macedo EC, Pascual-Leone A, Boggio PS. Transcranial direct current stimulation of the prefrontal cortex modulates the desire for specific foods. Appetite 2008;51(1):34-41. 
60. Imamura M, Imamura ST, Kaziyama HH, Targino RA, Hsing WT, de Souza LP, Cutait MM, Fregni F, Camanho GL. Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: a controlled analysis. Arthritis Rheum 2008;59(10):1424-31. 
61. Rigonatti SP, Boggio PS, Myczkowski ML, Otta E, Fiquer JT, Ribeiro RB, Nitsche MA, Pascual-Leone A, Fregni F. Transcranial direct stimulation and fluoxetine for the treatment of depression. Eur Psychiatry 2008;23(1):74-6. 
62. Rosa MA, Rosa MO, Belegarde IM, Bueno CR, Fregni F. Recovery after ECT: comparison of propofol, etomidate and thiopental. Rev Bras Psiquiatr 2008;30(2):149-51.  63. Wagner T, Eden U, Fregni F, Valero-Cabre A, Ramos-Estebanez C, Pronio-Stelluto V, Grodzinsky A, Zahn M, Pascual-Leone A. Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study. Exp Brain Res 2008;186(4):539-50. 
64. Boggio P, Oliveira MO, Fecteau S, Cohen RB, Campanha C, Ferreira-Santos E, Meleiro A, Corchs F, Zaghi S, Pascual-Leone A, Fregni F. A phase-II clinical trial of high-frequency rTMS treatment for post-traumatic stress disorder (PTSD) Journal of Clinical Psychiatry 2009;in press. 
65. Boggio PS, Amancio EJ, Correa CF, Cecilio S, Valasek C, Bajwa Z, Freedman SD, Pascual-Leone A, Edwards DJ, Fregni F. Transcranial DC stimulation coupled with TENS for the treatment of chronic pain: a preliminary study. Clin J Pain 2009;25(8):691-5. 
66. Boggio PS, Campanha C, Valasek CA, Fecteau S, Fregni F. Modulation of decision-making in a gambling task in older adults with transcranial direct current stimulation (tDCS). European Journal of Neuroscience 2009;in press. 
67. Boggio PS, Fregni F, Valasek C, Ellwood S, Chi R, Gallate J, Pascual-Leone A, Snyder A. Temporal lobe cortical electrical stimulation during the encoding and retrieval phase reduces false memories. PLoS One 2009;4(3):e4959. 
68. Boggio PS, Khoury LP, Martins DC, Martins OE, de Macedo EC, Fregni F. Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease. J Neurol Neurosurg Psychiatry 2009;80(4):444-7. 
69. Boggio PS, Liguori P, Sultani N, Rezende L, Fecteau S, Fregni F. Cumulative priming effects of cortical stimulation on smoking cue-induced craving. Neurosci Lett 2009;463(1):82-6. 
70. Boggio PS, Zaghi S, Fregni F. Modulation of emotions associated with images of human pain using anodal transcranial direct current stimulation (tDCS). Neuropsychologia 2009;47(1):212-7. 
71. Cardoso EF, Maia FM, Fregni F, Myczkowski ML, Melo LM, Sato JR, Marcolin MA, Rigonatti SP, Cruz AC, Jr., Barbosa ER, Amaro E, Jr. Depression in Parkinson's disease: convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus. Neuroimage 2009;47(2):467-72. 
72. Cohen RB, Boggio PS, Fregni F. Risk factors for relapse after remission with repetitive transcranial magnetic stimulation for the treatment of depression. Depress Anxiety 2009;26(7):682-8. 
73. Fenton B, Fanning J, Palmieri P, Boggio P, Fregni F. A preliminary study of transcranial direct current stimulation for the treatment of refractory chronic pelvic pain. Brain Stimulation 2009;2(2):103-7. 
74. Fiquer JT, Boggio PS, Silva MTA, Gorenstein C, Fregni F, Rigonatti SP, Otta E. Affective changes in depressed patients treated with Transcranial Direct Current Stimulation. Temas em Psicologia 2009;15(2):149-59. 
75. Martin PI, Naeser MA, Ho M, Doron KW, Kurland J, Kaplan J, Wang Y, Nicholas M, Baker EH, Fregni F, Pascual-Leone A. Overt naming fMRI pre- and post-TMS: Two nonfluent aphasia patients, with and without improved naming post-TMS. Brain Lang 2009;111(1):20-35. 
76. Valle A, Roizenblatt S, Botte S, Zaghi S, Riberto M, Tufik S, Boggio PS, Fregni F. Efficacy of anodal transcranial direct current stimulation (tDCS) for the treatment of fibromyalgia: Results of a randomized, sham-controlled longitudinal clinical trial. Journal of Pain Management 2009;2(3):353-64. 
77. Williams JA, Pascual-Leone A, Fregni F. Interhemispheric Modulation Induced by Cortical Stimulation and Motor Training. Physical Therapy 2009;in press.

Thank you all from the wonderful care you've given out mom. She was always in the best of hands! We appreciate all you've done.

The D. Family

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